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What is Domperidone used for?

Domperidone is a medication that primarily acts as a dopamine receptor antagonist. It is commonly used to address gastrointestinal issues, particularly those involving motility. Here are some key points::

1.  It is often prescribed to treat conditions like nausea and vomiting, and it is particularly effective in managing symptoms associated with certain gastrointestinal disorders.
2.  It works by blocking dopamine receptors in the GI (gastrointestinal) tract increasing the motility of the intestinal tract and stomach.
3.  The main uses include:
   • Gastrointestinal Motility: Gastroparesis (delaying the emptying of the stomach) is one of the primary reasons for use
   • Nausea and Vomiting: Alleviating symptoms of nausea and vomiting, especially post-surgery or chemotherapy
   • Gastrointestinal Motility: Gastroparesis (delaying the emptying of the stomach) is one of the primary reasons for use
   • Nausea and Vomiting: Alleviating symptoms of nausea and vomiting, especially post-surgery or chemotherapy.

It’s important to note that Domperidone is not designed to increase breast milk production/lactation during breastfeeding

Strengths and Manufacturer

As Domperidone is available in a generic form, it is produced by various pharmaceutical companies globally. Some common names for Domperidone include:

• Motilium (Brand name)
• Domperidone (Generic name)

Domperidone is available in various formulations, and its strengths may vary depending on the specific product and manufacturer.:

Motilium (Brand name for Domperidone) is manufactured by Janssen Pharmaceutica, a subsidiary of Johnson & Johnson. However, in different countries, Motilium may be manufactured and distributed by different pharmaceutical companies, per their local licensing agreements.

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Active Ingredients, Dosages & Side Effects

Domperidone, accompanied by inert ingredients meticulously chosen to uphold its stability and efficacy. This combination of active and inactive components is designed to ensure the medication’s overall effectiveness.

How to use?

Prescribed dosages are determined by various factors including the age and weight of the client, medical history, and individual response to treatment.

• Initial doses start at 10mg TWO to THREE TIMES daily
• The most common direction prescribed is 30mg daily (10mg, three times daily with each meal).

Dosages are adjusted based on the individual’s response to treatment, ensuring the most effective control of symptom management while minimizing adverse effects.

Side Effects of Domperidone

While generally well-tolerated, side effects can occur, such as (this list is not exhaustive):

Severe effects are rare but may include galactorrhea (excessive or spontaneous breastmilk production), menstrual irregularity, heart palpitations, and dizziness which may require immediate medical attention.

Warnings

Here is a list of cautions, about Domperidone:

• HEART RISK – heart rhythm disorder and sudden death (cardiac arrest) can occur.
  This occurrence is more likely with the elderly and those taking more than 30mg daily
  Your doctor may request an EEG (electroencephalogram) before and during your treatment.
• DO NOT use if you have signs of bleeding in the stomach or intestines
• DO NOT use with other medications that can affect the heart
• DO NOT use it if you suffer from an irregular heartbeat
• DO NOT use it if you are pregnant, or plan to become pregnant

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Storage Details

Ensure it is stored correctly at room temperature 15 – 30°C (59 – 86 F).

Improving breastmilk production

While this medication can be useful in gastrointestinal complications, it’s crucial to understand that it is not indicated for breastmilk stimulation, and using it for this purpose is seen as “Off-label”.

Prolactin, a hormone responsible for lactation and breast development, levels are increased during use, but the risk of cardiac events is greater at doses higher than 30mg daily. Typically doses used for milk production are 40 – 80mg daily, up to 250% higher than the maximal recommended dose.

Studies have shown safety concerns regarding using this medication.

It is not indicated in the USA, or any other country, for enhancing breast milk production in lactating women due to the risk of cardiac events.

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Gastrointestinal alternatives

Consulting healthcare providers about other medications or supplements used is crucial to managing potential interactions. Regular monitoring ensures effectiveness with minimized risks, available for purchase through reliable online platforms.

People who have bought this have also shown interest in products related to nausea and vomiting, seeking solutions for their specific health needs. These products may include various supplements and tools designed to support a healthier lifestyle.

Always consult with healthcare professionals for personalized advice and guidance on achieving your health and weight management goals.

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Frequently Asked Questions (FAQs)

► Why is Domperidone illegal in the US?

It is not approved by the Food and Drug Administration (FDA) for use in the USA. The FDA has expressed concerns about the potential for serious cardiac side effects associated with its use. These concerns include the risk of QT interval prolongation and ventricular arrhythmias leading to cardiac failure in high doses.

Doses up to 80mg per day are prescribed to increase milk production, while anything over 30mg daily has a higher-than-normal risk of causing QT prolongation, which can lead to cardiac issues.

► What is Domperidone used for?

It is primarily used to treat gastrointestinal issues such as nausea and vomiting. It works by blocking dopamine receptors in the brain and the upper digestive tract, which can help alleviate symptoms associated with certain conditions, such as gastroparesis.

► Who cannot take Domperidone?

DO NOT take:

• If you have:
  • Underlying cardiac diseases such as CHF (Congestive Heart Failure)
  • Moderate or severe liver issues
  • Severe electrolyte imbalances
• Whilst taking other drugs that can cause QT Prolongation
• If you have hypersensitivity to the medication or any of its ingredients

► What is a typical dose?

The recommended dosage is 10mg THREE times DAILY at any time of day, typically with meals.

Ask your Healthcare Professional for more information.

► How do you store?

Store at room temperature between 15 – 30°C (59 – 86 F).

DO NOT store above 30°C (86F)

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